Record added by Jurg Ott (the original Rockefeller list)
Extended Pedigree Disequilibrium Test
EPDT is a major advancement in detecting linkage/disequilibrium signals # between genetic markers and disease loci, particularly if only one # or a few large pedigrees are available. The strategy differs from # conventional approaches that require at least a moderate number of # families to attain adequate statistical power. The proposed testing # procedure is advantageous in that it provides high statistical power # coupled with reduced sample collection. Furthermore, the proposed # method avoids problems such as potential population stratification # and genetic heterogeneity, and is robust with respect to misspecification # of phenotype.
Cathy SJ Fann (Institute of Biomedical Sciences, Academia Sinica, Taiwan)
Yang, Chen, Fann “A pedigree-based disequilibrium test for a single extended pedigree”. preprint.