EPDT

Record added by Jurg Ott (the original Rockefeller list)

Full Name

Extended Pedigree Disequilibrium Test

Version

1.0 (2004)

Description

EPDT is a major advancement in detecting linkage/disequilibrium signals # between genetic markers and disease loci, particularly if only one # or a few large pedigrees are available. The strategy differs from # conventional approaches that require at least a moderate number of # families to attain adequate statistical power. The proposed testing # procedure is advantageous in that it provides high statistical power # coupled with reduced sample collection. Furthermore, the proposed # method avoids problems such as potential population stratification # and genetic heterogeneity, and is robust with respect to misspecification # of phenotype.

Author

  • Chun-Liang Chen

  • Cathy SJ Fann (Institute of Biomedical Sciences, Academia Sinica, Taiwan)

URL

http://www.ibms.sinica.edu.tw/~csjfann/first%20flow/programlist.htm

OS

UNIX

Reference

Yang, Chen, Fann “A pedigree-based disequilibrium test for a single extended pedigree”. preprint.