GENEFINDER

Record added by Jurg Ott (the original Rockefeller list)

Version

1.1.9 (June 2004)

Description

GeneFinder uses GEE method to estimate the location of the susceptibility gene based on the allele-sharing of affected sib pairs for multiple markers. GENEFINDER can further the analysis of GENEHUNTER by providing a more accurate gene location estimation and the corresponding confidence interval.

Author

  • Wei-Min Chen (email: wechen@jhsph.edu)

  • Kung-Yee Liang (email: kyliang@jhpsh.edu)

  • Yen-Feng Chiu

URL

http://www.biostat.jhsph.edu/~wmchen/gf.html

Language

C++

OS

MS-Windows, MS-DOS, UNIX(Solaris)

EXE

gf

Reference

  • Liang KY, Zeger SL (1986), “Longitudinal data analysis using generalized linear models”, Biometrika, 73: 13-22.

  • Liang KY, Chiu YF, Beaty TH (2001), “A robust identity by descent procedure using affected sib pairs: a multipoint approach for complex diseases”, Human Heredity, 51:64-78.

  • Liang KY, Chiu YF, Beaty TH, Wjst Matthias (2001), “A multipoint analysis using affected sib pairs: incorporation of linkage evidence from unlinked regions”, Genetic Epidemiology, 21:105-122.

  • Liang KY, Huang CY, Beaty TH (2000) A unified sampling approach for multipoint analysis of qualitative and quantitative traits in sib pairs. American Journal Human Genetics, 66(5):1631-1641

  • Glidden DV, Liang KY, Chiu YF, Pulver AE (2003), “Multipoint affected sibpair linkage methods for localizing susceptibility genes of complex diseases”, Genetic Epidemiology, 24:107-117