QUANTO

Record added by Jurg Ott (the original Rockefeller list)

Version

1.2.1 (January 2007)

Description

Quanto is a program that computes sample size or power for association studies of genes, environmental factors, gene-environment interaction, or gene-gene interaction. Available study designs for a disease (binary) outcome include the unmatched case-control, matched case-control, case-sibling, case-parent, and case-only designs. Study designs for a quantitative tra it include independent individuals and case parent designs. Quanto is a 32-bit Windows application requiring Windows 95, 98, NT, 2000, ME or XP to run. The graphical user interface allows th e user to easily change the model and view the results without having to edit an input file and rerun the program for every model. The results of a session are stored to a log file. This log can be printed or saved to a file for reviewing at a later date. An option is included to create a text file of the log that can be imported into other documents.

Author

  • Jim Gauderman (email: jimg@usc.edu)

  • John Morrison (email: jmorr@usc.edu)

URL

http://hydra.usc.edu/GxE

Language

C++

OS

Window(98/NT/2000/..)

EXE

quanto.exe

Reference

  • Gauderman (2002), “Sample size requirements for matched case-control studies of gene-environment interaction”, Statistics in Medicine, 21:35-50

  • Gauderman (2002), “Sample size requirements for association studies of gene-gene interaction”, American Journal of Epidemiology, 155:478-484

  • WJ Gauderman (2003), “Candidate gene association studies for a quantitative trait, using parent-offspring trios”, Genetic Epidemiology, 25:327-338