GENEHUNTER-MODSCORE

Record added by Jurg Ott (the original Rockefeller list)

Version

2.0 (October 2006)

Description

GENEHUNTER-MODSCORE is a further extension of GENEHUNTER-IMPRINTING. The program is based on the original GENEHUNTER version 2.1 release 6. GENEHUNTER-MODSCORE allows for a MOD-score analysis, in which parametric LOD scores are maximized over the parameters of the trait model, i.e., the penetrances and disease allele frequency. As of version 2.0, it is possible to use sex-specific recombination frequencies. The genetic positions of markers can be automatically read from a publicly available genetic map.

Author

Konstantin Strauch (strauch@med.uni-marburg.de) (Philipps University Marburg, Germany) Johannes Dietter (dietter@med.uni-marburg.de) (Philipps University Marburg, Germany)

URL

http://www.staff.uni-marburg.de/~strauchk/software.html

Language

C

OS

UNIX(SUNOS,Solaris,OSF,HPUX,AIX,Ultrix), Linux, MS-Windows

EXE

ghm

Reference

  • K Strauch (2003), “Parametric linkage analysis with automatic optimization of the disease model parameters”. American Journal of Human Genetics 73(Suppl1):A2624.

  • Dietter, Mattheisen, Fuerst, Rueschendorf, Wienker, Strauch (2007), “Linkage analysis using sex-specific recombination fractions with GENEHUNTER-MODSCORE”, Bioinformatics, 23(1):64-70.