GHOST

Record added by Jurg Ott (the original Rockefeller list)

Description

GHOST is a software package for family-based genomewide association (GWA) analysis, with the ability to infer missing genotypes using the Elston-Stewart algorithm. When SNPs from an association panel are less complete (i.e., having more missing genotypes) than markers from a linkage panel, many of the missing genotypes can be determined. GHOST can handle large pedigrees – when pedigrees are small, Merlin is also recommended for this analysis.

URL

http://www.sph.umich.edu/csg/chen/ghost/

Reference

  • Burdick, Chen, Abecasis, Cheung (2006), “In silico method for inferring genotypes in pedigrees”, Nature Genetics, 38:1002-1004.

  • Chen, Abecasis (2007), “Family-based association tests for genomewide association scans”, American Journal of Human Genetics, 81(5):913-926