IMPUTE

Record added by Jurg Ott (the original Rockefeller list)

Version

2 (2009)

Description

IMPUTE is a program for estimating (“imputing”) unobserved genotypes in SNP association studies. The program is designed to work seamlessly with the output of the genotype calling program CHIAMO and the population genetic simulator HAPGEN, and it produces output that can be analyzed using the program SNPTEST.

Author

  • Bryan Howie (email: bhowie@uchicago.edu)

  • Jonathan Marchini (email: marchini@stats.ox.ac.uk)

URL

https://mathgen.stats.ox.ac.uk/impute/impute.html

Reference

  • Marchini, Howie, Myers, McVean, Donnelly (2007), “A new multipoint method for genome-wide association studies via imputation of genotypes”, Nature Genetics, 39:906-913.

  • Howie, Donnelly, Marchini (2009), “A flexible and accurate genotype imputation method for the next generation of genome-wide association studies”, PLoS Genetics, 5(6):e1000529