Record added by Jurg Ott (the original Rockefeller list)
Secondary Phenotype REGression analysis
SPREG is a computer program for performing regression analysis of secondary phenotype data in case-control association studies. Secondary phenotypes are quantitative or qualitative traits other than the case-control status. Because the case-control sample is not a random sample of the general population, standard statistical analysis of secondary phenotype data can yield very misleading results. SPREG implements valid and efficient statistical methods.
Donglin Zeng (Univ North Carolina)
Lin, Zeng (2009), “Proper analysis of secondary phenotype data in case-control association studies”, Genetic Epidemiology, 33:256-265.