GC/GCF

Record added by Jurg Ott (the original Rockefeller list)

Full Name

Genomic Control

Description

GC implements the genomic control models. GCF implements the basic Genomic Control approach, but adjusts the p-values for uncertainty in the estimated effect of substructure. This approach is preferable if a large number of tests will be evaluated because it provides a more accurrate assessment of the significance level for small p-values.

Author

  • B Devlin

  • K Roeder

    URL

    http://wpicr.wpic.pitt.edu/WPICCompGen/genomic_control/genomic_control.htm

    Language

    R

    OS

    Linux

    Reference

  • Devlin, Roeder (1999), “Genomic control for association studies”, Biometrics, 55:997-1004.

  • Bacanu, Devlin, Roeder (2002), “Association studies for quantitative traits in structured populations”, Genetic Epidemiology, 22:78-93.

  • Devlin, Bacanu, Roeder (2004), “Genomic control in the extreme”, Nature Genetics, 36(11):1129-1130.