TDT-AE

Record added by Jurg Ott (the original Rockefeller list)

Full Name

Transmission Disequilibrium Test Allowing for Errors

Version

2.01 (July 2004)

Description

This program computes a likelihood-based transmission disequilibrium test. The data are genotypes on trios (father, mother, affected child) in which random genotyping errors leading to Mendelian inconsistencies may or may not have occurred. This program computes the TDT-AE statistic on all trios (whether Mendelianly consistent or not) and thereby maintains a correct type I error rate in the presence of random genotyping errors.

Author

  • Chad Haynes
  • Derek Gordon (email: Gordon@dls.rutgers.edu)

  • Xin Liu (for version 1)

    URL

    ftp://linkage.rockefeller.edu/software/tdtae2

    Language

    C

    OS

    MS-Windows (2000/DOS), UNIX(Sun Solaris), LINUX (RedHat)

    EXE

    tdt-ae (PC), tdtae (UNIX and LINUX)

    Reference

  • Gordon, Heath, Liu, Ott (2001), “A transmission/disequilibrium test that allows for genotyping errors in the analysis of single-nucleotide polymorphism data”, American Journal of Human Genetics, 69(2):371-380. [ html]

  • Gordon, Haynes, Johnnidis, Patel, Bowcock, Ott (2004), “A transmission disequilibrium test for general pedigrees that is robust to the presence of random genotyping errors and any number of untyped parents”, European Journal of Human Genetics, 12:752-761.

  • User’s Guide